"Sacrofano, what do you say if we get married?" This is how, in the midst of an autopsy, Claudio makes his marriage proposal to Alice. Meanwhile, a new director, Andrea Manes, and two first-year postgraduates, Giulia and Sandro, have arrived at the Institute of Forensic Medicine, while Professor Boschi, aka "Wally", is exiled to the basement.

Alice and Claudio begin preparations for the wedding, but she notices that he is hiding something from her. While Alice is working on the murder case of an old prof. in psychiatry, the historic friendship with Lara and Paolone is put to the test by the doctoral announcement: there are only two places up for grabs, the loser will have to leave the institute.

Alice is intrigued by the arrival of Giacomo, Claudio's brother with a wild and unconventional charm. He would like to know what has divided them in the past, but Claudio does not confide, even now that they are getting married. In any case, Alice's attention, rather than Claudio's reluctance, is focused on the Suprema: she appreciates its rigor and considers it a model of life totally different from what she had always imagined for herself. During the investigation into the murder of a sushi chef, Silvia confronts Alice about her working relationship with PM Einardi. At the institute Erika asks Paolone to help her conquer the fascinating Sandro who instead seems to have a keen interest in Alice. The first meeting between Giacomo and the Supreme generates sparks, leading Claudio to be even more irritated by the presence of his brother.

The investigation into the tragic accident that occurred to a stunt double during the shooting of a film captures Alice's attention, making her forget an appointment with Claudio. The relationship of love between the two becomes more and more turbulent, while Sandro, who supports her in the inspection, is increasingly fascinated by her. Marco has an important job opportunity that puts him and Lara at a crossroads. While working on the research that Manes has entrusted to her, Alice's unstoppable curiosity leads her to discover an unspeakable truth about the Supreme.

Alice and Claudio are at loggerheads for Giacomo's presence and for the numerous tasks entrusted to the student by the Supreme. By order of Manes, they are summoned to shed light on the death of an Olympic rifle champion killed in a firing range. Forced closeness doesn't make things better, while the Supreme senses that Alice has discovered her secret.

Alice is destroyed by suspicions of Claudio's betrayal and returns the engagement ring, sending him into a rage. To cheer her up, Wally involves her in her secret project and Silvia suggests reprisals. Meanwhile, a famous trapper is killed just before a concert and the difficult expertise is entrusted to the Suprema herself, who decides to take Alice with her. Sandro sees an opportunity and decides to come forward with Alice, but does not realize that Claudio has seen it all ...

Mutual jealousy causes sparks between Alice and Claudio, but Giacomo's sudden arrest calls everything into question. Claudio's brother is accused of the murder of an industrialist in a golf club. The motive is there and Silvia's investigations reveal unsuspected truths about Giacomo and Claudio's past to Alice and the Supreme. Alice and Claudio find themselves united in believing in Giacomo's innocence, even if all the evidence seems to confirm his guilt.

The death of an elderly playboy during the funeral of a friend of grandmother Amalia's and the unexpected involvement of her grandmother in the investigation push Alice and Lara to entrust Camilla to the most unlikely babysitter: Cordelia. Meanwhile, someone has enrolled Paolone in a cooking talent, but the outcome will not be quite what they hoped for. Alice has a formidable intuition that could prove Giacomo's innocence and to verify it goes beyond the limits of what is allowed.

Claudio does his utmost to protect Alice, but at the same time keeps her at a distance, while trying to prove Giacomo's innocence. Meanwhile, Lara asks Alice to collaborate on her first appraisal: a boy died while doing parkour and it is necessary to carry out the relevant findings. Just when Erika realizes that her feelings for Paolone go far beyond friendship, he moves away.

Claudio and Alice follow an intuition that can exonerate Giacomo. Paolone is also summoned for his first report: the mysterious death by poisoning of a well-known food critic. Alice's stubbornness, meanwhile, leads her to make one last attempt in the quest that the Supreme had given up.

Giacomo's provisional release re-starts the investigation into the crime at the golf club. Meanwhile, Alice discovers that someone is looking for information on Manes: perhaps the person she so desires to meet is closer to her than she imagines. For Alice and Claudio the day set for the wedding has arrived, but it passes in vain.