A true-crime enthusiast may help crack a missing persons case in Ohio.

An upscale apparel store in Bethesda, Md., is the site of a gruesome scene when an employee is killed and her co-worker is battered and tied up, but surveillance video and blood evidence shed further light on the crime.

Eight days after she had disappeared on her way to a family ski trip, an 18-year-old young woman's partially nude body is found floating in a river in Wyoming, Years later, DNA technology uncovers dark secrets that led to her demise.

California police are baffled when an innocent man's DNA is found at the scene of a deadly home invasion, and authorities team with the man's defense attorney.

A young Colorado mother suddenly vanishes on Thanksgiving, but when police trace her cell phone, it leads them to a surprising character with an even more surprising story.

A young mother is found murdered in her home and there are two suspects with ample motive, but an unusual interview and security camera footage have investigators puzzled.

After the discovery of the brutal murder of an 18-year-old desk clerk of a beachfront condo, analysts use brand-new mitochondrial DNA technology to prove the killer's identity.

July Fourth weekend leads to a tragedy for a California family; to catch a killer, detectives utilize an unorthodox technique—analyzing bug fragments—to help put a murderer behind bars.

A Texas love triangle turns deadly, and it appears to be an open-and-shut case until technology tells the tale.

A 33-year-old West Virginia husband and father seemingly dies in an accidental house fire; a closer look at the scene reveals a more sinister case.

A family mourns the unexpected death of a beloved grandmother at Christmas, and while local police assure everyone that she was the victim of a tragic accident and that there is no foul play, some things about the scene don't add up.

When the 20-year-old clerk of an Atlanta-area smoke shop is gunned down during a robbery, investigators have only descriptions of the killers and the make of their getaway car; investigators use a videotaped confession to smoke out the killers.